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What is Ranexa ?
Ranexa is an effective treatment option available for chest pain (angina) treatment. It is also known as ranolazine, and it is usually added to other drugs when they are not working well enough.
Ranexa belongs to the antianginal category of medications available on prescription only. However, it is not a controlled medicine. Here are the three primary forms of this drug:
- Ranexa 375 mg
- Ranexa 500 mg
- Ranexa 750 mg
Angina is a form of chest pain because of tight blood vessels in the heart. A typical starting dose of Ranexa 500 mg taken orally twice a day can help this medical condition. Your healthcare professional may increase the amount to 1000 mg orally twice a day.
Before taking Ranexa (ranolazine), ensure that your healthcare professional is aware of your medical history, especially if you have ever had:
- a heart rhythm disorder;
- kidney disease;
- liver disease; or
- an individual or family history of long QT syndrome
Pregnancy and Lactation Warnings
It is unknown whether Ranexa can harm an unborn baby. Although, tell your healthcare professional about your pregnancy or your plan to conceive. Also, it is unclear whether ranolazine can pass through breast milk or could harm a nursing baby. But you should inform the doctor if you are breastfeeding a nursing baby.
What does ranolazine do for the heart?
By reducing the calcium flow into the cells, ranolazine is believed to help the heart to relax. In the heart, this drug improves blood flow to the heart’s muscle and relieves the symptoms of angina pectoris.
What are Ranexa tablets used for?
Ranexa tablets are most used for angina (chest pain) treatment. This drug can be administered alone or in combination with other medications that can help treat chronic angina (continuous ongoing chest pain or pressure that can occur when the heart does not get enough oxygen).
What other drugs can interact with Ranexa?
Following are the drugs that may interact with ranolazine, and you should not use these drugs simultaneously. Your healthcare professional may need to make changes in your treatment plan if you take any of the following medicines:
- antifungal medicine- ketoconazole, itraconazole;
- St. John’s wort;
- tuberculosis medicine- rifampin, rifabutin, rifapentine;
- HIV or AIDS medications- nelfinavir, indinavir, lopinavir/ ritonavir, saquinavir, ritonavir; or
- seizure medicine- phenobarbital, carbamazepine, phenytoin
Several other drugs can interact with ranolazine. Below is a part of some medicines that you need to stop using while taking Ranexa:
- arsenic trioxide (Trisenox);
- aprepitant (Emend);
- digoxin (Lanoxin);
- chloroquine (Aralen);
- lovastatin (Altoprev, Mevacor, Advisor), simvastatin (Simcor, Zocor, Vytorin);
- fluconazole (Diflucan);
- tolterodine (Detrol);
- tamsulosin (Flomax);
- ADHD medication such as dextroamphetamine (Adderall), atomoxetine (Strattera), methylphenidate (Daytrana, Ritalin, Concerta, Metadate), methamphetamine (Desoxyn);
- an antibiotic such as erythromycin (EES, Erythrocin, EryPed, Ery-Tab, Pediazole), azithromycin (Zithromax), moxifloxacin (Avelox), levofloxacin (Levaquin), pentamidine (Pentium, NebuPent)
An antidepressant such as clomipramine (Anafranil), doxepin (Sinequan), amitriptyline (Vanatrip, Elavil, Limbitrol), imipramine (Tofranil), fluoxetine (Sarafem, Prozac, Symbyax) can also interact with Ranexa (ranolazine)