Showing the single result
All You Need to Know About Hydroxychloroquine
What is Hydroxychloroquine?
Hydroxychloroquine is antimalarial medicine that was discovered in 1934. It is on the WHO or World Health Organization’s List of Essential Medicines. It is available as a generic medication. Hydroxychloroquine is a member of the class of drugs called 4- aminoquinoline. As an antimalarial, Hydroxychloroquine works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell.
Hydroxychloroquine is mainly used to prevent and treat malaria in areas where malaria remains sensitive to its effects. Hydroxychloroquine is occasionally used for amebiasis outside rheumatoid arthritis, intestines, and lupus erythematosus. Hydroxychloroquine appears safe during pregnancy. It is taken by mouth. Buy Hydroxychloroquine 200mg online from our website to prevent the occurrence of malaria.
Hydroxychloroquine comes in tablet form as the sulfate, phosphate, and hydrochloride salts. Hydroxychloroquine is commonly dispensed as sulfate. Brand names of Hydroxychloroquine include Plaquenil, Dawaquin, and Largo. Buy Hydroxychloroquine 200mg online without a prescription from our site. We hope you have an effortless shopping experience.
Clinical trials of Hydroxychloroquine
Hydroxychloroquine has been clinically tried in the prevention and treatment of malaria. Hydroxychloroquine is also used to treat liver infections caused by protozoa (extraintestinal amebiasis). Hydroxychloroquine may also treat coronavirus (COVID-19) in certain hospitalized patients. Buy Hydroxychloroquine 200mg online through overnight delivery from us to protect yourself from the mentioned illnesses.
Trials of Hydroxychloroquine to treat malaria:
Hydroxychloroquine is used to prevent and treat malaria from P. malariae, Plasmodium vivax, and P. ovale. Hydroxychloroquine 200mg is generally not used in the case of Plasmodium falciparum as there is widespread resistance to it.
This drug has been extensively used in mass drug administrations, which might have contributed to the emergence and spread of resistance with Hydroxychloroquine. You must see if Hydroxychloroquine 200mg is still effective in the region before using it.
Patients can use Hydroxychloroquine with other medications or alone to treat amoebic liver abscesses.
For rheumatic disease:
As it mildly suppresses the body’s immune system, Hydroxychloroquine is used in some autoimmune disorders, like rheumatoid arthritis, and has an off-label indication for lupus erythematosus.
How should I take Hydroxychloroquine after buying it online?
Order Hydroxychloroquine online from our trusted online pharmacy store. Take Hydrochloroquine 200mg with food. Swallow the tablets with a glass of water. If you take a medicine for indigestion (such as an antacid), do not take it within two hours before or after taking Hydroxychloroquine.
Hydroxychloroquine works best when you take it on a regular schedule. Suppose you are taking it once a week to prevent malaria. It is best to take it on the same day of each week. Ensure that you don’t mix any dose of Hydroxychloroquine. If you have any questions regarding this, check with your doctor.
What should I avoid while taking Hydroxychloroquine?
Purchase Hydroxychloroquine 200mg online from us and contact us if you have any queries regarding your purchase. This medicine can cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you. Avoid taking an antacid or Kaopectate (kaolin-pectin) within four hours before or after taking Hydroxychloroquine.
What is the mechanism of action of Hydroxychloroquine?
The primary action of this drug is to inhibit the formation of Hz or hemozoin from the heme released by the digestion of hemoglobin (Hb). Hydroxychloroquine concentrates in the acidic food vacuole of the parasite and interferes with essential processes. The free heme then lyses membranes and causes parasite death. Hydroxychloroquine resistance is due to a decreased hydroxychloroquine accumulation in the food vacuole.
To explain it further, Hydroxychloroquine enters the red blood cell or RBC by simple diffusion, inhibiting the parasite cell and digestive vacuole. It then becomes protonated (to CQ 2+), as the digestive vacuole is acidic (pH 4.7). Hydroxychloroquine then can’t leave by diffusion. It caps hemozoin molecules that avoid further biocrystallization of heme, thus causing heme buildup.
Hydroxychloroquine binds to heme (FP) to form the FP- Chloroquine complex. The complex is highly toxic to the cell and disrupts the membrane function. The toxic FP- chloroquine and FP action lead to cell lysis and ultimately parasite cell autodigestion. Parasites that don’t form hemozoin are therefore resistant to Hydroxychloroquine.
In other terms, Hydroxychloroquine kills by concentrating in the parasite’s food vacuole and preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. The parasite then dies from the toxic by-products of its metabolism of hemoglobin.
What are the inactive and active ingredients of Hydroxychloroquine tablets?
Hydrochlooquine, 7- chloro-4- (4- diethylamino- 1 -methyl butyl amino)-quinoline, is made by reacting 4,7 -dichloro quinoline with 4-diethylamino -1- methyl butylamine at 180 degrees Celcius. Each Hydroxychloroquine tablet for oral administration contains 250 milligrams of hydroxychloroquine phosphate ( equivalent to 150 milligrams ) or 500 milligrams of chloroquine phosphate (equivalent to 300 milligrams base).
Inactive ingredients 250 milligrams: Calcium phosphate, Calcium stearate, Colloidal silicon dioxide, Dibasic Calcium phosphate, microcrystalline cellulose, and talc.
How long does Hydroxychloroquine stay in the body?
Hydroxychloroquine concentrations decline slowly, with an elimination half-life of 20 to 60 days. It can be detected in urine months after a single dose. If you must stop it, it will take a while for the side effects to disappear.
What are the side effects of Hydroxychloroquine?
Common side effects of Hydroxychloroquine include blurred vision, nausea, vomiting, loss of appetite, abdominal cramps, headache, diarrhea, swelling legs/ankles, shortness of breath, pale lips/ nails/ skin, muscle weakness, easy bruising or bleeding, and hearing loss.
Severe side effects include seizures, uncontrolled or unwanted movements, signs of severe infection, unpleasant metallic taste, chloroquine retinopathy, electrocardiographic changes, and pancytopenia.
What other drugs interact with Hydroxychloroquine?
Hydroxychloroquine has several drug-drug interactions that might be of clinical concern. Following are some drug interactions with Hydrochloroquine:
Ampicillin- Hydroxychloroquine can reduce levels;
Antacids- Hydroxychloroquine can reduce the absorption of Hydroxychloroquine;
Cimetidine- can inhibit the metabolism of Hydroxychloroquine; thus increasing levels of Hydroxychloroquine in the body;
Cyclosporine- Hydroxychloroquine can increase levels; and
Mefloquine- can increase risk of convulsions.
For more information or to buy Hydroxychloroquine, please feel free to contact us.