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What is Colcrys? Colchicine uses, doses and Side effects.

Colcrys is a prescription medication commonly used to:

  1. Prevent and treat gout flares in adults
  2. Treat familial Mediterranean fever (FMF) in adults and children age four or older.

Colchicine is not a pain medication, and it should not be taken to treat pain related to other conditions unless specifically prescribed for those conditions. This drug is used to treat gout attacks (flares). Usually, gout symptoms develop abruptly and involve only a few joints. The knee, big toe, or ankle joints are most usually affected. Gout is caused due to too much uric acid in the blood.

This medicine also prevents pain attacks in the chest, abdomen, or joints caused by a specific inherited disease (FMF or familial Mediterranean fever). Buy Colchicine online from our trusted pharmacy website because we deliver authentic medicines. Colcrys is thought to work by decreasing the body’s production of a particular protein (amyloid A) that builds up in people with FMF or familial Mediterranean fever.

How should I take Colcrys?

Order Colcrys 0.6mg online without a prescription from us. We hope you have a comfortable shopping experience with us.  You can take colchicine with or without food. Don’t stop taking Colcrys even if you start to feel better unless your doctor tells you. Your doctor can do blood tests while you take Colcrys.

Tell your doctor if you have a gout flare while using Colcrys 0.6mg daily.

What is the recommended dosage of Colchicine?

If you are taking this drug to treat a gout attack, carefully follow the directions given by the doctor. This medicine works best if you take it at the first sign of an attack. The recommended dosage is 1.2 mg at the first sign of an attack, followed by 0.6 mg one hour later.

The maximum recommended dose is 1.8 mg taken over one hour. Enquire your doctor about how soon you can repeat treatment with this medication if you have another gout attack. Buy Colcrys 0.6mg online through overnight delivery from our site. If you are using Colchicine to prevent gout attacks or pericarditis, ask the doctor about the dosage and schedule, you must follow. Carefully follow the doctor’s directions.

If you are using Colcrys to prevent attacks of pain caused by familial Mediterranean fever, the usual dosage is 1.2 to 2.4 mg daily. The total dosage may be taken once daily or divided into two doses a day. The doctor may need to adjust your quantity to control your symptoms or if you have side effects. The dose is based on your medical condition, other foods/drugs you may be taking, and your response to the treatment. To reduce your risk for severe side effects, don’t increase your dose, take it more frequently, or take it for a longer duration than directed by the doctor. Severe side effects could occur even at the usual prescribed doses.

If the doctor directs you to take colchicine regularly, use it regularly to get the most benefit from the drug.

What should I know before taking Colcrys?

Purchase Colcrys online from us, and we ensure a guaranteed return and full refund if you have any issue with the product delivered by us. Before taking this medication, tell your pharmacist or doctor if you are allergic to it or have any other allergies. This product can contain inactive ingredients, which may cause allergic reactions or other problems. Talk to the pharmacist for more details.

Before using this medication, tell the doctor or pharmacist your medical history, especially liver problems (such as cirrhosis) and kidney problems. This medication may affect how well your body absorbs nutrients (such as vitamin B12) and foods. Consult the doctor or pharmacist for more details.

Before having surgery, tell the doctor or dentist that you take Colcrys. Older adults can be more sensitive to the side effects of this medicine, especially numbness/tingling in their fingers or toes and muscle weakness/pain.

Colchicine may decrease sperm production, which can affect the ability of a male to father a child. Consult the doctor for more information. During pregnancy, this medication must be used only when needed. Discuss the benefits and risks with your doctor. This medicine passes into breast milk. Your doctor can recommend that you separate the times you take your medicine apart from breastfeeding.

What should I avoid while using Colcrys?

Order Colcrys 0.6mg online from us because we are the most reliable pharmacy website in this country. Avoid consuming grapefruit while being treated with this medication unless the doctor instructs you otherwise. Grapefruit may increase the level of certain medications in your bloodstream. Alcohol can reduce this drug’s effectiveness. Limit alcohol intake while taking this drug.

How long does Colcrys take to work on gout?

Colchicine begins to work after around 30 minutes to 2 hours. However, it can take a day or two before you notice your pain and inflammation get better. If you are taking it to prevent flare-ups of FMF, you may not feel any difference.

What is the half-life of Colcrys?

Colchicine is quickly and almost completely absorbed after oral administration. Maximum plasma concentrations are often met after 30 minutes to two hours. The terminal half-life is three to ten hours.

What is the mechanism of action of Colcrys?

The primary mechanism of action of colchicine is tubulin disruption. This causes subsequent downregulation of multiple inflammatory pathways and modulates innate immunity.

Colchicine decreases swelling and lessens the build-up of uric acid crystals that cause pain in the affected joint. Colcrys is also commonly used to prevent pain attacks in the chest, abdomen, or joints caused by a particular inherited disease FMF (or familial Mediterranean fever).

What are the inactive and active ingredients in Colcrys?

Colcrys 0.6mg capsules  are supplied for oral administration. Each tablet contains 0.6-milligram Colcrys and inactive ingredients:  lactose anhydrous, colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, and sodium starch glycolate.

What are the potential side effects of Colcrys?

Colcrys can cause severe side effects. Following are the side affects you may experience while taking Colchicine:

  • Muscle weakness or pain
  • Unusual bleeding or bruising
  • Numbness or tingling in your toes or fingers
  • Increased infections or feel weak or tired
  • Severe diarrhea or vomiting
  • Pale or gray color to your tongue, lips, or palms of your hands

Don’t take Colcrys if you have kidney or liver problems and use certain other medicines. Severe side effects, including death, have been reported in such patients even when taken as directed.

What other drugs can interact with Colcrys?

Using Colcrys with certain other medicines, such as digoxin and cholesterol-lowering medications, may affect each other, causing severe side effects. The doctor may need to change your dosage of Colchicine. Talk to the doctor about whether the drugs you are taking might interact with Colcrys and what side effects to look for.

To help the doctor and pharmacist give you the best care, tell your doctor and pharmacist about all the products you use (including nonprescription drugs, prescription drugs, and herbal products) before starting treatment with Colcrys. While using Colcrys, don’t start, stop, or change the dose of any other medicines you are taking without the doctor’s approval.

Other medications may affect the removal of Colcrys from your body, which can affect how Colcrys works or increase the risk of severe side effects. Examples include diltiazem, HIV medications (such as ritonavir), certain azole antifungals (such as itraconazole, ketoconazole), telithromycin, verapamil, macrolide antibiotics (such as clarithromycin, erythromycin), among others.

Colchicine may rarely cause particularly severe (even fatal) muscle damage (rhabdomyolysis). This muscle damage releases substances that may lead to severe kidney problems. The risk may be increased if other medications that can also cause rhabdomyolysis are taken along with Colcrys. Some affected drugs include pravastatin, simvastatin, digoxin, gemfibrozil, among others.

Colcrys can interfere with certain laboratory tests, possibly causing false test results. Ensure laboratory personnel and all your doctors know you take this drug.

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